Molluscicide

NOMENCLATURE
Niclosamide
Common name niclosamide (BSI, E-ISO, (m) F-ISO, BAN, Germany (for veterinary use))
IUPAC name 2', 5-dichloro-4'-nitrosalicylanilide
Chemical Abstracts name 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
CAS RN [50-65-7]

PHYSICAL CHEMISTRY
Niclosamide
Mol. Wt. 327.1
M. F. C13H8Cl2N2O4
Form Almost colourless crystals.
M. P. 230 º C
V. P. <1 mPa (20 º C)
KOW logP = 1 (pH 9.6)
Solubility In water 1.6 (pH 6.4), 110 (pH 9.1) (both in mg/l, 20 º C). Soluble in common organic solvents such as ethanol and diethyl ether.
Stability Hydrolysed in aqueous solution, DT50 (20 º C) c. 7 d (pH 6.9), 18.8 d (pH 13.3). Stable to heat. Decomposes under u. V. Irradiation. Hydrolysed by concentrated acid or alkali.

APPLICATIONS
Mode of action
Molluscicide with respiratory and stomach action.
Uses
Control of golden apple snail in rice. Control of schistosomiasis and fascioliasis in man by killing fresh-water snails which act as intermediate hosts. Also used for veterinary control of tapeworm infestations.

Niclosamide
Compatibility Incompatible with acidic materials.
Selected tradenames: 'Bayluscide' (EC250) (Bayer)
Formulation types WP.