Red Clover Extract

Product Description

Red clover, a beautiful flower with three leaves in stem, really is a lovely herb. There is a nice story about it. Every leaf of clover stands for a kind of bless. The first one stands for "hope", the second one for "faith", and the third one for "love". Furthermore, if you could find the fourth leaf, you would get "luck". Many people looked for it year after year. Regretfully, the four-leaf clover is just like a beautiful fairy, couldn't be discovered.
However, scientists now give us an opportunity. They have found that there are good active ingredients in it. Lots of isoflavones, such as Biochanin A, Formononetin, Genistein, Daidzein are rich in its leaves. Experiments show taking isoflavones is beneficial to our health. Red clover, a wonderful herb, brings us health and protects us free away from disease.

Active Ingredients: Isoflavones
Biochanin A Fomononetin Genistein Daidzein
Isoflavones are one of most characteristic classes of chemical compounds in higher plants. From a chemical points of view, they comprise a wide group of structurally related compounds with a chromane skeleton provided a phenyl substitute at C3 position. Natural isoflavones widely distribute in Legume family. However, the number and quantity of isoflavones are greatly different in different herbs. Red clover currently is considered as the herb which contains the most isoflavones. Biochanin A, Fomononetin, Genistein and Daidzein are mark active isoflavones. Specially, biochanin A is a major isoflavone extracted from red clover while it hardly exists in soy-derived extracts.

History
Red clover was originally used as a medicinal herb by native indigenous people of North America for whooping cough, gout and cancer. And traditionally, some people also used it in the treatment of asthma, bronchitis, coughs, and dermatophytosis, etc.

Natural Phytoestrogen
The isoflavones structures of red clover extract are similar with estrogen. Therefore, they can activate estrogen receptors(ER). Jonathan T. C. Reported that product extracted from the leaves of red clover bind the ER effectively. The ER activity is contacted intimately with women estrogen level in body. Women will decrease estrogen level with age and cause related bone density problem. Charlotte Atkinson, enrolled women aged 49 to 65 years (N = 205) in a double-blind, randomized, placebo-controlled trial to test red clover extract for loss of Lumbar Spine Bone Density. The result is positive after 1 year administration of red clover isoflavones.

Activity on Menopausal
Peter et al reported that menopausal women treated with 80 mg isoflavones per day resulted in a significant reduction in hot flushes from baseline. At the end of the 12 weeks, there was a significant decrease in hot flushes of 44% between the active and placebo group, demonstrating the effectiveness of red clover extract in the management of hot flushes.

Activity on Cancer
In vitro studies showed biochanin A and genistein affect cellular expression of NADPH: Quinone reductase in colonic cells. The result suggests biochanin A and genistein may be implicated in colorectal cancer chemoprevention.
The study of prostate cancer cell LNCaP was cultured with Biochanin A indicated that biochanin A inhibits prostate cancer cell growth through induction of cell cycle arrest and apoptosis. Biochanin A-regulated genes suggest multiple pathways of action. Biochanin A inhibits the incidence and growth of LNCaP xenograft tumors in athymic mice.

Clinical experiment studied by Jarred RA et al estimated intake of dietary isoflavones may halt the progression of prostate cancer by inducing apoptosis in low to moderate grade tumors.

Antioxidant acitivy and improving immunity

Lowers LDL cholesterol in men