Chlorquinaldol/Promestriene Vaginal Tablets
[Ingredients] Chlorquinaldol 200mg;Promestriene 10mg
[Description] It is ivory-white or light yellow tablets.
[Indications] Used for leucorrhea abnormality caused by varieties of infectious pathogenies, excepting gonorrhoeae.
[Administration & Dosage] wetting the tablet and delivering it to the deep part of the vagina, 1 tablet each night, administrating for 18 days, it should keep taking during the menses, and the dosage should be adjusted according the doctor's advice.
[Adverse Reactions] Adverse reaction is infrequent, only few patients have adverse reaction of local stimulus, itching or burning sensation during therapy, especially at the initial stages, the symptom vanished after stop taking this product.
1.Although there is no systemic effect in the application process, the application for patients who has estrogen-dependent disease is not advocated.
2.Allergy person to this product is banned.
[Precaution] The patients with estrogen-dependent disease avoid the use of this product.
[Pharmaco-toxicology] This product is a compound consisting of Chlorquinaldol and Promestriene.Chlorquinaldol is a broad-spectrum antimicrobial agent, it can inhibits a wide range of pathogens.The research shows that comparing with the traditional topical formulations of estrogen, the capability of Promestriene to penetrating vaginal or epidermis epithelial cells is weaker, so the reaction of absorbing of whole body, as well as the systemic response to sex hormones is very slight, for local administration, Promestriene has the function of anti-atrophy of vagina or cervix.
[Pharmacokinetics] Chlorquinaldol a contacted antimicrobial agent, the amount absorbed by the vaginal mucosa is limited and will not metabolize in the vagina.Promestriene administrated locally does not gather inside of tissues, its biological half-life less than 24 hours.Application on the skin, only less than 1% of Promestriene was absorbed, after vaginal administration, there is no systemic hormones effects has been observed, especially at estrogen-sensitive organs those are more distant from the vagina(such as breast and the uterus).
[Storage] sealed, place in dry place.
[Package] 6 tablets/ board / box + fingerstall
[Validity] 24 months
[Approval No.] GYZZ H20051504