Basic Info.
Function
Cardiovascular Agents, Selective and specific heart rate inhibitors
Grade Standard
Medicine Grade
Storage
room temperature of 20 -25°C
Appearance
White to light yellow powder
Use
Selective and specific heart rate inhibitors
Classification
Cardiovascular API
Product Description
Product Description
Star products in JANUARY 2022--HyperChem |
Identification |
Name | Ivabradine Hydrochloride |
Other names | Ivabradine hydrochloride 148849-67-6 Ivabradine HCl Procoralan Ivabradine (hydrochloride) |
CAS number | 148849-67-6 |
Molecular Formula | C27H37ClN2O5 |
Molecular Weight | 505.05 |
EINECS | 638-798-3 |
Chemical and Physical Properties |
Appearance | White to off-white powder |
Melting point | 193-196°C |
Quality standard | CP/USP |
Application |
Drug Indication/Application | Ivabradine Hydrochloride is the hydrochloride salt form of ivabradine, an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker, with negative chronotropic activity. Upon administration, ivabradine selectively binds to the intracellular portion of the HCN channel pore and blocks HCN channels in the pacemaker cells within the sinoatrial (SA) node.
This inhibits the If (funny) pacemaker ion current, prevents the inward flow and intracellular accumulation of positively charged ions, reduces pacemaker activity and slows diastolic depolarization. This decreases heart rate, reduces myocardial oxygen demand and allows more time for blood to flow to the myocardium without affecting cardiac contractility. HCN channels, mixed sodium (Na+) and potassium (K+) channels that carry the inward If current, play a key role in the regulation of pacemaker firing rate in the SA node. The If pacemaker current, the inward flow of positively charged Na+-K+ ions, initiates the spontaneous diastolic depolarization phase and modulating heart rate.
|
Formulations/Preparations | Tablet Powder for Suspension Tablet, Chewable Tablet, Extended Release Capsule |
Handling and Storage |
Safety and Hazards | The Shanghai Research Institute of Chemical industry testing center identification conclusion :1 No hazard identification, 2 The substance is not subject to IATA DGR, 3 Nonpacking requirements. |
Handling and Storage | Store at a controlled room temperature 20 -25°C (68 -77°F) |
Sample package | Double plastic bags inside, aluminum foil bag outside |
Commercial package | Double plastic bags inside,5kg, 10kg, and 25kg fiber drum outside. |
UN Code | Not classified |
HS Code | / |
Shipping group | Shipment at ambient temperature for no controlled and no dangerous goods |
Sales restriction | No |
Origin | China |
Technnical support |
Ivabradine hydrochloride,STD Data sheet Ivabradine hydrochloride,MSDS Ivabradine hydrochloride,COA Ivabradine hydrochloridet,Transport Certificate | Yes Yes Yes Yes |
Company Profile
Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials
produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials
to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements
companies worldwide.
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FAQ
Q1 What is the Hyper chem payment term?
T/T advance
LC at sight
DP at sight
Trade assurance
Western union
Money gram
Q2 What is Hyper chem shipment policy?
Our policy is to strive for the quickest shipment time possible, with ready stock sample shipment typically going out the same day that your order was placed. Your satisfaction is very important to us.
For non-ready stock, please contact Hyper Chem sales team to negotiate.
Q3 What hyper chem will provide after shipment?
For sample orders:
After shipment is done, an timely email including:
- Track details (Fedex /TNT/DHL/EMS Track number)
- Package photo
- COA, MSDS, etc
- Dispatch date & Estimated arriving time
- Shipping invoice
For commercial orders
A full set of shipment documents as well as package photos can be provided
in scan-copy and original, to help customers complete the customs clearance process.
Q4 What is Hyper Chem shipment term?
By Express
DHL FedEx TNT EMS
Fast:5 days around
High cost, door to door service
By-Air
Suitable for more than 50kg
Fast :3-7 days Hight cost, port to port, professional broker needed
By sea
Suitable for more than 500kg
Slow:7-45 days, Low cost, port to port, professional broker needed
We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.
Q5. Does hyper chem provide a shipment return policy?
Yes, we have.
Return Policy: At Hyper chem, your satisfaction is guaranteed. If you are dissatisfied for any reason with a product, please send back the unused portion along with your packing slip and a brief note on why you were dissatisfied within 45 days of purchase for a full refund to:
Hangzhou Hyper Chemicals Limited
No.188 Hongxing Rd,
Hangzhou,310005,
Zhejiang, China
Sorry, we cannot accept packages without postage/freight prepaid.
Q8 What is hyper chem After-sales service
Documents support: COA ,MSDS, MOA ,MS Report,HNMR Report,SDS,DMF
• Customer Support: Shipment clearance support, quality issue support
• Automated Customer Service: Our worldwide customers enjoy immediate 24/7 access to the HYPER CHEM support team from any location, at any time.
Address:
Room 803, Tower 4, Loft49 Creative City Pioneer Zone, No. 88 Jiru Road, Gongshu District, Hangzhou, Zhejiang, China
Business Type:
Manufacturer/Factory, Trading Company
Business Range:
Agriculture & Food, Chemicals, Health & Medicine, Packaging & Printing, Textile
Management System Certification:
ISO 9001, GMP
Company Introduction:
Greetings and salutations, we hope you are doing well and pray for this to continue onwards. Allow us to introduce ourselves. We are Hangzhou Hyper Chemicals Limited, an international supplier of pharmaceutical raw materials. Experts in providing raw materials, resources, customized manufacturing, and much more.
We especially provide ourselves with the supplying of high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients. Among them, our key client industrial sectors around the globe are:
Pharmaceuticals:
Nutrition ingredients/ Dietary supplements
Cosmetic Ingredients:
Veterinary Drug
Agriculture fertilizer
Custom Synthesis lab supply
HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation. We are trusted by big names who trust us in providing them with world-class and top-quality products.